The prognosis of acute myeloid leukemia (AML) can be made based mostly on peripheral blood or bone marrow blasts. On this evaluate, we are going to focus on the function of bone marrow analysis and peripheral blood monitoring within the prognosis, management, and comply with up of AML patients. For patients with circulating blasts, it's reasonable to perform the mandatory research wanted for prognosis and threat stratification, together with multiparametric stream cytometry, cytogenetics, and molecular analysis, on a peripheral blood specimen. The day 14 marrow is used to doc hypocellularity in response to induction chemotherapy, but it's unclear if that assessment is critical as it often doesn't affect immediate management. Currently, response assessments performed at depend recovery for evaluation of remission and measurable residual illness rely on bone marrow sampling. For monitoring of relapse, peripheral blood analysis may be satisfactory, but the sensitivity of bone marrow testing is in some instances superior. While bone marrow evaluation can certainly be averted particularly situations, this cumbersome and uncomfortable process at present remains the de facto standard for response assessment.

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